Coenzyme Q₁₀ is a powerful antioxidant that is involved in all the biochemical reactions in the body. It helps generate energy within the mitochondria (factories) of cells. It is found in every cell of the body but is present in higher concentrations in organs with greater energy demands such as the heart, liver, brain, kidneys and lungs. It is particularly important to maintain heart muscle cells and support the health of blood vessels.
- As an antioxidant, CoQ₁₀ protects proteins, LDL (“bad”) cholesterol, and mitochondrial DNA from oxidative damage.*
- As a participant in the production of cellular energy, CoQ₁₀ helps ensure the body’s biggest energy consumers— the heart and the brain— are well fed.*
Thanks to these two crucial functions, CoQ₁₀ helps maintain blood pressure already within normal limits,¹ supports the integrity of heart muscle,² increases circulation to the heart,³ improves exercise capacity, ⁴ ' ⁵ and supports a normal heart rhythm.*⁶ Additionally, it may protect against mild memory problems associated with aging. ⁷ ' ⁸ *
Who Should Take HYPERIG Ubiquinol (Superior CoQ₁₀)?
HyperIg Ubiquinol is the perfect nutritional supplement for everyone:
HyperIg Ubiquinol is the perfect nutritional supplement for anyone who wants to: decrease inflammation, protect cells from oxidative damage due to excessive free radicals, enhance exercise performance, reduce fatigue, support one’s heart, lung and brain, have healthy glucose utilization, maintain sperm and egg health, support skin's youthful appearance, and decrease headaches and migraines. Recent evidence suggests that supplementation with CoQ₁₀ may also be useful for supporting enhanced liver health.
People who are healthy can easily convert ubiquinone (the form of CoQ₁₀ featured in most supplements) to ubiquinol (the form used by the body to neutralize free radicals and create energy). But as we age, we produce less CoQ₁₀ and we become less efficient at converting ubiquinone to ubiquinol. By providing CoQ₁₀ already reduced to its ubiquinol form, as it is in the HyperIg Ubiquinol, the body is supplied with a more ready-to-use form of CoQ₁₀. It helps individuals increase and maintain their blood levels of CoQ₁₀.
Elevated Levels of Oxidative Stress*
One of the primary benefits of CoQ₁₀, particularly in the ubiquinol form featured in HyperIg Ubiquinol, is to provide antioxidant protection.* HyperIg Ubiquinol acts an electron donor, which means it can help neutralize unstable free radicals (oxidants) — without becoming a free radical itself.*
Statins
Certain medications, such as statins and certain conditions such as heart disease, can deplete CoQ₁₀ levels in the body. Supplementation with ubiquinol can restore CoQ₁₀ stores to normal levels. Additionally, some studies have concluded that supplementation with CoQ10 reduces muscle pain in individuals taking statins. ¹¹
Cardiovascular and Brain Health*
Because of its role in energy production, CoQ₁₀ supports the functioning of organs with a high demand for energy, such as the heart and brain.* The heart muscle in particular is in constant need of a ready supply of energy to efficiently pump blood throughout the body. In fact, the majority of cardiac tissue is abundant in mitochondria requiring ample and consistent levels of CoQ₁₀ for proper functioning.*
Increase Levels of CoQ₁₀
Most people don’t eat enough foods containing CoQ₁₀ — such as fatty fish, organ meats, and whole grains — to raise blood levels of this vitamin-like essential nutrient. In fact, the average dietary intake of CoQ₁₀ is only 3-5 mg a day, much lower than what’ s needed to have any effect on CoQ₁₀ concentrations. Because ubiquinol is in a more bioavailable form, it has can increase levels of CoQ10 in the body more effectively than CoQ₁₀ by itself.
hYPERIG Ubiquinol Is Safe and highly Bioavailable
“Study on safety and bioavailability of ubiquinol after single and 4-week multiple oral administration to healthy volunteers.”
A single-blind placebo-controlled study published in Regulatory Toxicology and Pharmacology found that doses of up to 300 mg of ubiquinol were safe and bioavailable.
In the first phase of the study, ¹⁵ healthy subjects were administered a single dose of either 150 mg or 300 mg of Kaneka QHTM. The treatment:
- Showed significant absorption in the gastrointestinal tract after both doses.
- Achieved peak plasma CoQ₁₀ levels (1.88 μg/ml for the low dose and 3.19 μg/ml for the high dose) 6 hours after administration.
A longer phase of the study followed 78 healthy subjects who took three different doses of Kaneka QHTM (90 mg, 150 mg, or 300 mg) or a placebo for 4 weeks.
The results showed that:
- CoQ₁₀ levels rose in a dose-dependent fashion for the entire treatment period — reaching a peak plasma concentration of 7 μg/ml at 28 days for the 300-mg group.
- CoQ₁₀ levels approached peak plasma levels after two weeks and then rose more slowly for another two weeks.
- Once supplementation ceased, plasma CoQ₁₀ levels dropped back to baseline levels after two weeks, indicating the need for on-going supplementation.
Hyperig uBIQUINOL
Why HyperIg Ubiquinol?
- Several factors can deplete CoQ₁₀. Research shows that aging, certain medications such as statin drugs, and certain disease states can deplete CoQ₁₀ levels in the body. Therefore, for many people, supplementation to replenish CoQ₁₀ is essential.
- CoQ₁₀ in crystalline powder form is difficult to absorb. Because of its highly lipophilic (fat-loving) structure, CoQ₁₀ is practically insoluble in water, making its absorption poor, highly variable, and strongly dependent on stomach contents. Plus, the CoQ₁₀ molecule is large in size, contributing to its poor absorption.
- The most effective solution for achieving CoQ₁₀ bioavailability is complete solubility. HyperIg Ubiquinol is a completely soluble, liquid, crystal-free solution of CoQ₁₀.This patent-pending formula combines ubiquinol with ingredients that protect it from being oxidized and crystallized.
- HyperIg Ubiquinol is already in the reduced ubiquinol form. The body produces CoQ₁₀ in the ubiquinone form, but it converts it to ubiquinol for use in neutralizing free radicals and generating energy.* With age, we become less efficient at this conversion process. HyperIg Ubiquinol starts working immediately upon ingestion and absorption — no conversion needed.
- HyperIg Ubiquinol is stable. Ubiquinol easily oxidizes and converts back to ubiquinone on contact with air. HyperIg Ubiquinol features Kaneka QHTM, a patented and stabilized form of ubiquinol that is protected from oxidation.
- Ubiquinol has clinically proven superior bioavailability. A double-blind study found that, compared to a single dose of 100 mg of standard CoQ₁₀ crystalline powder, a single dose of 100 mg of ubiquinol resulted in higher levels of CoQ₁₀ in the blood.
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Ubiquinol Highlights
HyperIg Ubiquinol is a completely soluble, formulation, clinically demonstrated to be more absorbable by the body than conventional CoQ₁₀ products.
HYPERIG Ubiquinol is:
- Great for vegetarians
- All-natural
- Gluten-free
- Pesticide-free
- Non-GMO
- Certified Kosher
REFERENCES
Ubiquinol (Superior CoQ₁₀)
A completely soluble, 100% crystal-free formulation of CoQ₁₀ in the ubiquinol form, with clinically proven superior bioavailability.
References
¹ Yamagami T, et al. Bioenergetics in clinical medicine. Studies on coenzyme Q₁₀ and essential hypertension.
Res Commun Chem Pathol Pharmacol. 1975; 11:273.
² EBSCO Publishing. “Cardiomyopathy.” Consumerlab.com. Accessed June 9, 2009.
http://www.consumerlab.com/tnp.asp?chunkiid=21484#ref1
³ EBSCO Publishing. “Cardiomyopathy.” Consumerlab.com. Accessed June 9, 2009.
http://www.consumerlab.com/tnp.asp?chunkiid=21484#ref1
⁴ Kamikawa T, et al. Effects of coenzyme Q₁₀ on exercise tolerance in chronic stable angina pectoris. Am J Cardiol. 1985 Aug 1;56(4):247-51.
⁵ Wilson, M.R., et al. Coenzyme Q₁₀ therapy and exercise duration in stable angina. In: Folkers, K., Littami, G.P.,
Yamogami,T. (eds), Biomedical and Clinical Aspects of Coenzyme Q₁₀, vol. 6,Amsterdam. Elsevier;1991:339-348.
⁶ Singh RB, et al. Randomized double-blind placebo-controlled trial of coenzyme Q₁₀ in patients with acute myocardial infarction. Cardiovasc Drugs Ther. 1998;12:347-353.
⁷ Muller T, et al. Coenzyme Q₁₀ supplementation provides mild symptomatic benefit in patients with
Parkinson’s disease. Neurosci Lett. 2003;341:201-204.
⁸ Young AJ, et al. Coenzyme Q₁₀: A Promising Treatment for Alzheimer’s Disease? Abstr Academy Health Meet. 2004; 21: abstract no. 1715.
⁹ Not all CoQ₁₀ products are created equal. Insiders Health. Feb. 20, 2009.
http://www.insidershealth.com/article_print/not_all_coq10_products_are_equal/2621
¹⁰ Palamakula A et al. Preparation and in vitro characterization of self-nanoemulsified drug delivery systems of
coenzyme Q₁₀ using chiral essential oil components. Pharm Tech. 2004; 74.
¹¹ Skarlovnik, A, et al. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study. Med Sci Monit. 2014;20:2183-2188.
Current literature suggests that CoQ10 is relatively safe with few drug interactions and side effects.
CAUTION: According to the Mayo Clinic, USA, CoQ10 may make blood-thinning drugs, such as warfarin (Coumadin, Jantoven), less effective. This could increase the risk of a blood clot. As with all supplements, if on prescription medications, consult with a health practitioner.