Health Practitioners FAQ

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·  Where can I obtain a Health Provider Fact Sheet on HyperIg PL100?

 Thank you for your inquiry. Please view HyperIg PL100's full information here - PDR.net

· How are hyperimmune eggs produced?  

“Hyperimmune” eggs (or “immune” eggs) are obtained from hens repeatedly exposed to a multivalent collection of inactivated bacteria. (No viruses, etc. are utilized).

· What immune components are found in "hyperimmune" eggs?

Repeatedly stimulating with the multivalent cocktail results in eggs containing specific immunoglobulins against the organisms to which the hen was exposed and a 30-fold increase in the concentration of bioactive, immunoregulatory factors.

· How can "hyperimmune" eggs protect an organism non-specifically against pathogens that were not in the stimulating inoculum? 

Stimulation of immune cells with multivalent mixtures results in generation of a large variety of immunoregulatory factors that able to non-specifically activate cells to search and destroy.

· What is IgY? 

IgY is an avian immunoglobulin equivalent to mammalian of IgG. Phylogenetically, IgY is more similar to IgE and secretory IgA than it is to IgG. IgY is found in high concentrations in yolk and functions similarly to mammalian IgG.

· How does IgY compare to mammalian antibodies such as IgG?

Due to phylogenetic differences, IgY has many biochemical and immunological advantages over mammalian immunoglobulins. In contrast to IgG, IgY does not activate the human complement system or react with rheumatoid factors or bacterial or human Fc receptors. Structurally, IgG has a longer hinge region making it more flexible than avian IgY.  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617726/

· What is the mechanism of action of the gastroprotective immunoglobulins in "hyperimmune" eggs? 

When immunoglobulins (antibodies) from “hyperimmune” eggs are introduced orally into the intestinal tract they adhere to and neutralize pathogens in the intestines. The protein adheres to the intestinal wall.  The immunoglobulins stay in the gut for days until the antigen-antibody complexes, or free immunoglobulin, is excreted along with the stool.

· Is consumption of "hyperimmune" egg analogous to mammalian passive transfer of immunity?

Yes. Over a period of time, nursing mammals passively transfer nutrients, growth factors and other immune products to protect their offspring until the young’s own immune system has matured. Since avians are not “designed” to nurse and have only a single opportunity to pass on immunity, immunity is passively transferred in a highly concentrated form via the egg.

· Do the specific immunoglobulins cross the gastrointestinal barrier?

Orally administered immunoglobulins from either egg or colostrum, do not cross the gastrointestinal barrier, and do not enter the systemic circulation.

· Is there any evidence suggesting a difference in the degree of passive protection by colostrum obtained from specifically vaccinated cows, as compared to that of eggs from chickens specifically vaccinated with the same organisms?

In studies of coronavirus-induced disease in calves, egg immunoglobulins were reported to be 4 times more efficient than those from colostrum in lowering intestinal viral titers and inhibiting diarrhea and mortality.6In vitro, IgY immunoglobulins demonstrate increased sensitivity as well.

· Is there a connection between the gut and immune function?

The intestine is the largest immunological organ in the body. It comprises more than 70-80% of all immunoglobulin-producing cells and produces more secretory IgA than the total production of IgG in the body. [In humans, IgG is only a minor component of secretions and affects, inefficiently, events within the intestinal lumen.]. In mammals, IgA directed against bacteria appears to prevent attachment of organisms and their toxins to the gut lining. It should not be surprising that the immune system is so well represented in the gut, since the oral passage is the portal and primary site of introduction for living organisms into the body. Additionally, one may wish to review the massive literature available on the cross-talk between gastrointestinal immune cells and the gut microbiome.

· Are orally administered IgY immunoglobulins entirely degraded by intestinal digestive enzymes?

The literature supports the fact that a significant portion of orally administered immunoglobulins remain active while passing through the intestines.

· The following factors contribute to the stability of IgY:

1. Even if the Fc portion of the IgY molecule (which is analogous to IgG found in mammals) is degraded, the active (Fab) unit can still form a complex with antigens.

2. The liposomic materials and proteins naturally found in egg may microencapsulate immunoglobulins protecting them from degradation, and

3. Immunoglobulins are designed to be bioavailable and bypass digestive processes (e.g., colostrum).

· Is consumption of hyperimmune IgY compatible with secretory IgA produced in mammals?

IgY is more closely related to IgA and IgE than it is to IgG.

· Why do many report energy changes upon consumption of "hyperimmune" eggs?

The human being has over 10¹⁴ single cells in the body. Ninety percent (90%) of these are non-human, foreign microbes with the majority of them residing in the gastrointestinal tract. Most of the gut microbiome are beneficial, however, when pathogens enter, they can potentially overwhelm immune responses and become a major threat to our well-being.

A great deal of energy is expended by the body to control the levels of pathogenic gut organisms. One might envision a scenario in which providing additional immunoglobulins to the gut may neutralize organisms that attempt to adhere to the inside of the intestines. Additionally, the body is continuously working to maintain immunological homeostasis. Each cell is attempting to either up- or down-regulate immune responses, trying to achieve immune homeostasis. Each cell expends a “trivial” amount of energy in modulating responses.

A “trivial” amount of energy multiplied by the billions of cells in the body becomes an enormous outlay of energy resulting in fatigue. As the body achieves homeostasis, less energy is needed to maintain homeostasis resulting in more energy for the individual.

·  I have more questions about HyperIg PL100. Who may I contact?

 Hellen Greenblatt, PhD holds non-royalty patents on the hyperimmune egg technology and has published extensively. Dr. Hellen Greenblatt - Publications & Patents (drhellengreenblatt.info)

Dr. Hellen looks forward to any and all inquiries. She can be reached directly at: 302.562.8000 (c), 302.265.3870 (o) or drhellen@drhellengreenblatt.info. 

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HyperIg PL-100™ is an all-natural protein that helps the body return to immunological balance. 

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